Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity
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چکیده
منابع مشابه
Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity.
The mammalian target of rapamycin complex 1 (mTORC1) is the key signaling hub that regulates cellular protein homeostasis, growth, and proliferation in health and disease. As a prerequisite for activation of mTORC1 by hormones and mitogens, there first has to be an available pool of intracellular amino acids. Arginine, an amino acid essential during mammalian embryogenesis and early development...
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ژورنال
عنوان ژورنال: eLife
سال: 2016
ISSN: 2050-084X
DOI: 10.7554/elife.11058